GS04 1103 Principles of Therapeutics
Zhang, Shuxing. Three semester hour. Spring, annually. Grading System: Letter Grade. Prerequisite: basic understanding of biochemistry and cell biology
This course will establish a foundation of the principles of therapeutics. It will introduce students to principles and history of therapeutics and teach them where we are in drug development. The course is structured so that students get introduced to human genome and causes of disease. A session will focus on target identification, protein crystallography, molecular modeling, and structure-based drug design and medicinal chemistry that will include drug design, synthesis, optimization, lead product identification, and chemical synthesis of lead product. Other session will focus on how chemicals serve as genetic modifier and introduce students to high throughput drug screening and siRNA screening. Toxicity and pharmacology play a major role in drug design, drug dosing, drug schedule, and route of administration. Role of biomarkers, genomics, and proteomics will be included with an emphasis on therapeutics. Students will be introduced to diverse strategies for therapy that includes natural products, immunotherapy, gene therapy, and blood and marrow transplantation. Process of moving a drug from laboratory to clinic will finish the course and will introduce students to translational and clinical research.