GS04 1223 Fundamental Mechanisms of Cancer Development

Gan, Boyi; Chen, Jichao. Three semester hours. Fall, annually. Grading System: Letter Grade. Prerequisite: None.

Cancer is defined by a series of abnormal events in the cell that lead to the formation of a tumor with the ability to spread to distant sites. Some hallmarks of cancer include aberrant proliferation, genomic instability, evasion of cell death and immune responses, and activation of a variety of cell growth signaling pathways.  This course is organized into weekly modules consisting of 2 lectures and a journal club. Each module is organized to first describe each of these events as they occur during normal development or homeostasis followed by a lecture on how these processes or pathways go awry to develop cancer. The last lecture of each module consists of a journal club with class-wide discussions of a recent or classic paper in the field. Module topics will be fundamental, timely, and cutting edge including signaling pathways, cancer genomics, non-coding RNAs and metabolism in cancer and therapy.  The teaching philosophy emphasizes development of critical thinking and understanding of central concepts through class discussion and weekly journal clubs. 

Course Outline Fundamental Mechanisms of Cancer Development