Dr. Sheng Pan
The University of Texas Health Science Center at Houston
McGovern Medical School
Institute of Molecular Medicine
Proteins are the essential functional biomolecules that are involved in all sorts of cellular physiologic activities, and have been important targets for drug development and early detection of diseases. Our lab is interested in applying mass spectrometry based proteomics and other molecular techniques to study disease-associated proteome alterations at a functional level. These studies are carried out with various goals, aiming to better understand the molecular mechanisms underlying tumorigenesis, to investigate changes in PTM status associated with diseases, and to identify cancer associated protein biomarkers to improve diagnosis or therapeutic treatment. Currently, our main disease focuses are pancreatic ductal adenocarcinoma, as well as other GI-tract malignancies and chronic inflammatory diseases. In addition, through collaborative efforts, our lab also supports proteomics investigation of neurological diseases, other types of cancers, GI-tract microbiome, infectious diseases and therapeutic drug development. Bioinformatics and systems biology are important components in our study for analysis of protein interaction networks and regulatory pathways associated with cancer and other disease mechanisms. Our works aim to apply and innovate clinical proteomics to facilitate mechanistic studies and biomarker discovery to facilitate early detection, treatment selection and drug development.