Dr. Linghua Wang
The University of Texas MD Anderson Cancer Center
Department of Genomic Medicine
My lab is interested in developing and applying innovative bioinformatics approaches to better understand the tumor ‘ecosystem’, particularly, the cellular & functional heterogeneity and evolutionary dynamics of tumor cells and tumor microenvironment (TME), the regulatory networks of anti-tumor immune response, the molecular & genomic determinants of tumor response to anti-cancer therapies, through high-dimensional (multi-platform, longitudinal, and spatial) profiling of tumor cells and their TME.
We perform integrative computational analysis of data generated from the cutting-edge technologies including single cell RNA/DNA/immune repertoire sequencing, single cell mass cytometry (CyTOF), mass spectrometry proteomics, whole transcriptome sequencing, TCR/BCR sequencing, Nanostring gene expression panels, whole-exome sequencing, targeted deep sequencing, and whole-genome sequencing, with the aim to identify new ‘drivers’ that promote tumor transformation/metastasis/drug resistance, understand the regulatory pathways/networks of immunosuppressive TME, find predictive biomarkers/signatures of therapy response, and discover novel clinically actionable targets. In addition, we are also interested in developing single cell analytic tools.