Dr. Mian M. Alauddin
The University of Texas MD Anderson Cancer Center
Department of Cancer Systems Imaging
My research involves radiosynthesis (using 18F-fluoride) of biologically active molecules to target specific enzymes or receptors that are overexpressed in cancer cells, so that the tumor can be visualized by PET. The specific molecules are nucleoside analogues to target human thymidine kinase TK1 and TK2, herpes virus thymidine kinase (HSV1-tk) gene expression; and histone deacetylase (HDAC) substrates for imaging HDAC activity in the brain.
Projects: Students will have the opportunity to identify projects for development of new PET radiotracers. Students will receive training in organic synthesis, radiosynthesis using 18F-fluoride, safe handling of high dose radiation, purification of the radioactive compounds, and quality control analysis and dose preparation for in vitro studies and in vivo animal and human use.