MD Anderson Cancer Center UTHealth
Graduate School of Biomedical Sciences

Dr. Kai Sun

Dr. Kai  Sun

Regular Member

Assistant Professor

The University of Texas Health Science Center at Houston
McGovern Medical School
Institute of Molecular Medicine

Research in my laboratory examines the essential contributions of adipocyte-derived factors to the dynamics of adipose tissue remodeling during obesity development and pinpoints them as critical factors with clinical significance in the pathophysiology of human obesity and diabetes. Specifically, we explore the fine-tuned regulation at multiple levels during the pathological expansion of adipose tissue in obese individuals.  The dynamic process includes hypoxia, angiogenesis and fibrosis. More recently, we use molecular tools and mouse models to study endotrophin, a small fibrotic molecule that we recently identified. All our findings highlight endotrophin as an attractive target for obesity and type 2 diabetes.

RESEARCH PROJECTS: 

  1. Hypoxia induced fibrosis and local inflammation in adipose tissue.
  1. VEGF-A stimulated metabolic benefits during adipose tissue healthy expansion.
  1. The effects of antiangiogenic action by blocking VEGF-A and/or its receptors in the context of preexisting adipose tissue (unhealthy expansion).
  1. The mechanisms by which endotrophin shapes unhealthy microenvironment in obese adipose tissue.
  1. Reversibility of adipose tissue fibrosis by novel anti-fibrotic therapies.

PubMed

IMM Faculty

Contact Information

Phone: 713.500.3190

Email: kai.sun@uth.tmc.edu

Office: SRB 437A

Education:

Ph.D. - University of California- Riverside - 2005

Programs:

Faculty is Currently: