Dr. Qiang Shen
The University of Texas MD Anderson Cancer Center
Department of Clinical Cancer Prevention
Dr. Shen’s primary research interest is to 1) elucidate the mechanisms by which normal cells malignantly transform and cancer cells progress to metastasize, and 2) develop innovative strategies for blocking carcinogenesis and controlling metastasis. Current research focuses on breast cancer biology, cancer prevention, metastasis, metabolism, and anti-cancer drug development, covering transcription factors (STAT3 and AP-1), kinases (glucose metabolism enzymes and HIPK isoform), apoptotic proteins (Bax and Bcl-2), ion channels and related signaling (KCNK5, TRPM7, and MCU), and development of targeted small molecule anti-cancer drugs for preventive and therapeutic applications (targeting STAT3, AP-1, Bax, HIPK, and NRF-2/RHOA/ROCK pathway, etc.). Particularly, breast cancer development/ metastasis and prevention have been long-standing themes in Shen laboratory, with a keen interest in developing strategies for the prevention and treatment of ER-negative, triple-negative, resistant ER-positive subtype breast cancer, and other cancers. Long-term goal is to translate the research discoveries into clinical use for preventing and treating breast cancer and other cancers. Two major short-term goals for the next 5-7 years are to elucidate the role of: 1) Aberrant glucose metabolism in mammary carcinogenesis and the development of targeted glucose metabolism modulators as preventive and therapeutic drugs for clinical trials, and 2) HIPK kinase as a driving determinant of cancer metastasis and the development of targeted anti-HIPK/anti-metastasis therapy. With a current focus of cancer metabolism for targeted cancer prevention and therapy, Shen lab is moving to a broader metabolism field with potential new directions for metabolic disorders and cancer development, such as obesity/diabetes and cancer development/intervention.
Office: MDA BSRB S7.8136C (Unit 1013)
M.D., M.S., Kunming Medical University, 1989
Ph.D., University of Texas Medical Branch, 2002