Dr. Jin Seon Im
The University of Texas MD Anderson Cancer Center
Department of Stem Cell Transplantation and Cellular Therapy
My research is focused on investigating CD1 antigen presenting system and CD!-restricted T cells in immune-regulation, More recently, we have been investigating the role of CD1d-restricted invariant Natural Killer (iNK) T cells in immune-regulation post allogeneic stem cell transplantation through translational approach, and developing novel cellular therapy using ex vivo expanded iNK T cells to prevent Graft Versus Host Disease (GVHD) using murine xenograft GVHD model. We will further enhance Graft Versus Leukemic effect of iNK T cells targeting tumor antigens using genetic modification with chimeric antigen receptors. Our research strategy involves various methods commonly employed in immunology research, ranging from basic molecular and cellular immunology to in vivo animal studies, not limiting to molecular cloning, protein expression, novel NGS-based single T cell transcriptome analysis, multi-color flow cytometry etc.