Dr. Jennifer M. Bailey
The University of Texas Health Science Center at Houston
McGovern Medical School
Department of Internal Medicine - Gastroenterology, Hepatology and Nutrition
The overall research program in the Bailey lab is centered on understanding the biology of precancerous and cancerous lesions in the gastrointestinal system, with a focus on the molecular processes that regulate the transition from normal epithelium to cancer. For a number of years, we have employed specific lineage-traced genetically engineered mouse models to examine the molecular, morphological, and genetic changes in pancreatic epithelial cells after activation of oncogenic KrasG12D. In addition, we use these models to understand chronic inflammatory processes that increase the risk for the accumulation of oncogenic mutations in the pancreatic epithelium. There are a number of funded projects in the lab related to these ideas, and our overall goal is to better define therapeutic strategies for the personalized treatment of pancreatic and other GI malignancies.
Three main goals underscore the work in my lab: 1) Identify the genetic, epigenetic, whole transcriptome, and paracrine signaling events that drive epithelial regeneration and transformation, 2) better understand the genetic and epigenetic processes that regulate cellular plasticity and 3) to identify the genetic and epigenetic events that regulate how different cell types respond to the accumulation of mutations that drive neoplastic progression.
A tutorial in the Bailey lab would include experience with immunohistochemistry, confocal microscopy, cell culture and flow cytometry. We comprehensively use GEM models and human tissue specimens to address a number of targeted hypotheses related to our three main goals.