Mark Hamilton
Assistant Professor
The University of Texas MD Anderson Cancer Center at Houston
Department of Lymphoma and Myeloma
I am an MD/PhD physician scientist currently working as an Assistant Professor in the Department of Lymphoma and Myeloma at MD Anderson Cancer Center. I have recently completed extensive training at Baylor College of Medicine (MD, PhD) and Stanford (residency and fellowship) and am now establishing my own independent laboratory.
Diffuse large B-cell lymphoma (DLBCL) is the most common form of lymphoma. DLBCL is treated in the first line with chemoimmunotherapy and in the second line with CAR T-cell therapy. Lymphoma therapy is curative in the first- and second-line setting but can cause substantial toxicities. We can use genomic technologies to understand 1) how the cancer responds to anti-cancer therapy including tracing changes in tumor burden using blood samples and 2) how anti-cancer therapies impact the patient’s immune system. The combination of this data will allow safer and more effective anti-cancer treatments.
My laboratory focuses on using human samples to understand lymphoma therapy and the interaction of lymphoma therapies with hematopoiesis. I use computational methods including cell free DNA sequencing, immune repertoire sequencing, single cell RNA sequencing, and single cell DNA sequencing to understand how tumors kinetically change over time. I use isolated peripheral blood cells to understand how anti-cancer therapies alter the immune system.
A rotation in my laboratory will focus on developing laboratory skills geared towards generation of next-generation libraries, and computational skills focused on understanding the generated libraries. This would specifically include understanding lymphoma treatment with chemoimmunotherapy and cellular therapy, using cell free DNA to trace tumor burden after treatment, and using genome sequencing and single cell sequencing to understanding the immune system changes associated with lymphoma therapies.
Education & Training
PhD, Baylor Graduate School, 2017
MD, Baylor Medical School, 2018