October’s Paper of the Month reveals how a conserved protein complex across species may unlock new clues to Huntington’s disease
The answers to human diseases may lie in the biology we share across species. In his recent studies, Stephen Farmer, a PhD student in the Molecular and Translational Biology and Neuroscience programs in Sheng Zhang, PhD’s lab at the Brown Foundation Institute of Molecular Medicine, investigated how conserved protein structures across species can advance understanding of Huntington’s disease. His findings show that the HTT-HAP40 complex is structurally conserved from model systems to humans and that a small region of HAP40, the BΦ motif, is crucial for HTT function — providing new insight into potential therapeutic targets for this neurodegenerative disorder.
October 31, 2025
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