July’s Paper of the Month explores how RNA modifications by TRMT1L ensure cell health during oxidative stress
Genetics and Epigenetics graduate student Sseu-Pei Hwang’s research unveils how TRMT1L-mediated modifications in tRNA are critical for efficient protein synthesis and cell survival under stress. Her innovative approach using nanopore-based tRNA sequencing uncovered TRMT1L’s role in maintaining cellular balance, especially under oxidative stress conditions. Hwang’s work enhances our understanding of RNA modifications linked to cancer development, opening new avenues for targeted therapies and emphasizing the intricate connections between RNA modification, translation efficiency, and disease progression.