MS Public Seminar: CATALINA VALDES BUSTAMANTE
When & Where
March 2
2:00 PM - 3:00 PM
UTHealth Houston, McGovern Medical School, MSB 7.037 (View in Google Map)
Contact
- Joy A. Lademora
- 7135009872
- [email protected]
Event Description
Effect of Anti-Microbial Immunization in the Progression of Amyloid and Neuroinflammatory Pathologies in a Mouse Model of Alzheimer’s Disease
Catalina Valdes Bustamante (Advisor: Rodrigo Morales, PhD)
Introduction: Vaccines are commonly used to protect against bacterial and viral pathogens. Recent reports suggest that immunizations can protect the brain against diverse insults, including those linked with dementia. However, comparative studies assessing the protective role of different immunization types against Alzheimer’s disease (AD) have not been conducted.
Methods: LPS and immunizations against coronavirus disease 19 (COVID-19), influenza and pneumonia, were administered to APP/PS1 mice modeling brain amyloidosis characteristic of AD. Cognitive and pathological features were evaluated and compared with control mice treated with PBS.
Results: As expected, immunizations and LPS administrations induced inflammatory changes in peripheral compartments. Interestingly, vaccinations against COVID-19 and influenza induced specific inflammatory profiles in the brain that were linked with improved cognitive properties and amelioration of pathology compared with controls and mice immunized against pneumococcus.
Discussion: These findings support clinical evidence suggesting that anti-microbial vaccinations protect the brain from neurodegenerative insults. Importantly, this report demonstrates the neuroprotective effects of vaccinations against COVID-19.
Advisory Committee:
- Rodrigo Morales, PhD, Chair
- Wei Cao, PhD
- Anjali Chauhan, PhD
- Paul Schultz, MD
- Sonia Villapol, PhD
Effect of Anti-Microbial Immunization in the Progression of Amyloid and Neuroinflammatory Pathologies in a Mouse Model of Alzheimer’s Disease
Catalina Valdes Bustamante (Advisor: Rodrigo Morales, PhD)
Introduction: Vaccines are commonly used to protect against bacterial and viral pathogens. Recent reports suggest that immunizations can protect the brain against diverse insults, including those linked with dementia. However, comparative studies assessing the protective role of different immunization types against Alzheimer’s disease (AD) have not been conducted.
Methods: LPS and immunizations against coronavirus disease 19 (COVID-19), influenza and pneumonia, were administered to APP/PS1 mice modeling brain amyloidosis characteristic of AD. Cognitive and pathological features were evaluated and compared with control mice treated with PBS.
Results: As expected, immunizations and LPS administrations induced inflammatory changes in peripheral compartments. Interestingly, vaccinations against COVID-19 and influenza induced specific inflammatory profiles in the brain that were linked with improved cognitive properties and amelioration of pathology compared with controls and mice immunized against pneumococcus.
Discussion: These findings support clinical evidence suggesting that anti-microbial vaccinations protect the brain from neurodegenerative insults. Importantly, this report demonstrates the neuroprotective effects of vaccinations against COVID-19.
Advisory Committee:
- Rodrigo Morales, PhD, Chair
- Wei Cao, PhD
- Anjali Chauhan, PhD
- Paul Schultz, MD
- Sonia Villapol, PhD