MS Public Seminar: FENGXI YE
When & Where
July 17
1:00 PM - 2:00 PM
UTHealth Houston, MD Anderson Cancer Center, BSRB S3.8371 (GSBS Large Classroom) and via Zoom (View in Google Map)
Contact
- Joy A. Lademora
- 7135009872
- [email protected]
Event Description
The Role of Cleavage and Polyadenylation Specific Factor 6 (CPSF6) in Hematopoiesis
Fengxi Ye, BM (Advisory: M. James You, MD, PhD)
Cleavage and polyadenylation specific factor 6 (Cpsf6) translocation is frequently reported in APLL, which is Acute Promyelocytic Leukemia (APL)-like acute myeloid leukemia (AML) and other types of blood diseases associated with abnormal hematopoiesis. CPSF6 is a subunit of the Cleavage Factor I mammalian (CFIm) complex, which regulates post-transcriptional alternative polyadenylation (APA) of pre-mRNAs. Previous research indicated that Cpsf6 plays an essential role in alternative polyadenylation, development, and tumorigenesis. However, the role of Cpsf6 in hematopoiesis is unknown. Given its roles in APA, development and cancer, we hypothesize that Cpsf6 plays a critical role in hematopoiesis and that its dysregulation may have significant impacts on this process. To test this, we used conditional knockout mouse models to examine the function of Cpsf6 in both embryonic and adult hematopoiesis. Our findings demonstrate that Cpsf6 is essential for embryonic hematopoiesis but is dispensable for maintaining adult hematopoietic homeostasis.
Advisory Committee:
- James You, MD, PhD, Chair
- George Calin, MD, PhD
- Shih-Han Lee, PhD
- Sean Post, PhD
- Angela Ting, PhD
- Pamela Wenzel, PhD
Join via Zoom (Please contact Ms. Ye for her Zoom meeting information.)
The Role of Cleavage and Polyadenylation Specific Factor 6 (CPSF6) in Hematopoiesis
Fengxi Ye, BM (Advisory: M. James You, MD, PhD)
Cleavage and polyadenylation specific factor 6 (Cpsf6) translocation is frequently reported in APLL, which is Acute Promyelocytic Leukemia (APL)-like acute myeloid leukemia (AML) and other types of blood diseases associated with abnormal hematopoiesis. CPSF6 is a subunit of the Cleavage Factor I mammalian (CFIm) complex, which regulates post-transcriptional alternative polyadenylation (APA) of pre-mRNAs. Previous research indicated that Cpsf6 plays an essential role in alternative polyadenylation, development, and tumorigenesis. However, the role of Cpsf6 in hematopoiesis is unknown. Given its roles in APA, development and cancer, we hypothesize that Cpsf6 plays a critical role in hematopoiesis and that its dysregulation may have significant impacts on this process. To test this, we used conditional knockout mouse models to examine the function of Cpsf6 in both embryonic and adult hematopoiesis. Our findings demonstrate that Cpsf6 is essential for embryonic hematopoiesis but is dispensable for maintaining adult hematopoietic homeostasis.
Advisory Committee:
- James You, MD, PhD, Chair
- George Calin, MD, PhD
- Shih-Han Lee, PhD
- Sean Post, PhD
- Angela Ting, PhD
- Pamela Wenzel, PhD
Join via Zoom (Please contact Ms. Ye for her Zoom meeting information.)
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