Skip to Content

Sandor Karpathy

Alumnus

Accepted post-doctoral position at Centers for Disease Control after receiving PhD
Now employed as Chief- Microbiology Laboratory- Rickettsial Zoonoses Branch- Centers for Disease Control and Prevention, Atlanta

The genomes of Fusobacterium nucleatum subspecies polymorphum strain ATCC 10953, Rickettsia typhi strain Wilmington, and Francisella tularensis subspecies holarctica strain OSU18 were sequenced, annotated, and analyzed. Each genome was then compared to the sequenced genomes of closely related bacteria. The genome of F. nucleatum ATCC 10953 was compared to two additional F. nucleatum subspecies, subspecies nucleatum and subspecies vincentii. This analysis revealed substantial evidence of horizontal gene transfer and indicate that the species of F. nucleatum has an open pan-genome. R. typhi was compared to R. prowazekii and R. conorii. This analysis uncovered a hotspot for chromosomal rearrangements in the Spotted Fever Group but not the Typhus Group Rickettsia and revealed the close genetic relationship between the Typhus Group Rickettsia. F. tularensis OSU18 was compared to two additional F. tularensis strains. These comparisons uncovered significant chromosomal rearrangements between F. tularensis species due to recombination between insertion sequence elements.

 

Search pubmed for papers by S Karpahty and G Weinstock

Research Info

Whole Genome Analysis of Fusobacterium nucleatum, Rickettsia typhi,and Francisella tularensis.