Skip to Content
Sivareddy Kotla

Sivareddy Kotla

Associate Member

Associate Professor

[email protected]
Zayed Z9.3028

The University of Texas MD Anderson Cancer Center
Department of Cardiology

Besides the significant improvement in patient survival rate, modern cancer therapies including chemotherapy, radiotherapy, targeted therapy and immunotherapy, main cause of the cardiotoxicity and cardiovascular complications. The molecular pathways that contribute to cancer therapy-associated cardio toxicity and cardiovascular complications are not well understood. The Kotla’s main research aim to understand the molecular pathways that contribute to cardio toxicity associated with the cancer treatments. The primary research goal of our laboratory is to understand the molecular mechanisms of atherosclerosis formation and heart failure as driven by shear stress, and specific cancer therapies with research interests that include: (1) determine the effects of Ionizing radiation(IR) on senescence-associated secretory phenotype (SASP) and develop novel therapies to inhibit SASP, as well as subsequent CVD and improve long-term survival of the victims following a radiation public health emergency and (2) Determine the role of p90RSK in IR-induced SASP and subsequent atherosclerosis (AS), (3) Verify the role of the ERK5 -NRF2 module in the IR-induced Mitochondrial dysfunction, SASP and Atherosclerosis. (4). Investigating the role of PARP1 activation-mediated metabolic changes including NAD+ depletion and their impact on Myeloid cell Senescence-associated reprogramming and Radiation induced cardiovascular diseases. (5). Determine the role of SARM1, TOP2b, and NAD+/BH4 co-depletion in d-flow–induced EC dysfunction and atherosclerosis invivo and SARM1-TOP2b network regulated BH4 and BH4 cycle–related metabolite changes after d-flow

We employ a wide range of biochemical, molecular biological, and biological techniques, such as multi-OMICS approaches – metabolomics, Bulk RNA sequence, scRNA sequence, CyTOF, IMC, imaging, and DNA cloning, protein expression in bacteria and mammalian cells, various biochemical assays, mammalian cell culture, proteomic techniques, chromatin immunoprecipitation, quantitative real-time PCR assays, mouse atherosclerosis models, various genetically modified mouse models.


MDACC Faculty

Education & Training

PhD, Jawahartal Nehru Technological University, 2013