The University of Texas Health Science Center at Houston
McGovern Medical School
Department of Pediatric Surgery
Dr. Triolo, an expert in clinical cell therapy manufacturing for regenerative medicine applications, directs the Judith R. Hoffberger Cellular Therapeutics Laboratory and the Evelyn H. Griffin Stem Cell Therapeutics Research Laboratory within the Program of Regenerative Medicine. The Hoffberger laboratory is focused on translating, scaling-up, validating and supporting Investigational New Drug (IND) applications – Chemistry, Manufacturing & Control (CMC) section – of promising new therapeutic technologies developed by scientists and physicians at a preclinical level into clinical-grade processes that can be used to manufacture cell-based and/or tissue engineered products for clinical applications. The Griffin Laboratory is an FDA-registered facility where tissues and organs are processed to produce cells for clinical applications in compliance with current Good Manufacturing Practice (cGMP).
Despite dramatic advancements in medical and surgical care, effective clinical therapies for neurological injury are limited. The past decade’s rapid advancement in stem cell biology and neurology has generated a growing body of literature supporting the use of various progenitor cell types to treat acute neurological injuries. In this context, Dr. Triolo’s lab is actively involved in several research endeavors of the Program of Regenerative Medicine. These include the development of human adult and fetal cell-based therapies to improve neurological conditions, such as anoxic brain injury at birth, cerebral palsy, traumatic brain injury and stroke, all of which are still unmet medical needs that have not been able to be satisfied by conventional healthcare therapies. Dr. Triolo’s research interests also include the development of innovative autologous tissue engineering applications based on extra-embryonic tissues (e.g., Amniotic Fluid, Wharton’s Jelly).
Education & Training
Ph.D. - University of Palermo - 1999
Ph.D. - Mount Sinai School of Medicine - 2002