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Junjie Chen

Junjie Chen

Regular Member


[email protected]
Zayed Z6.3038

The University of Texas MD Anderson Cancer Center
Department of Experimental Radiation Oncology

My laboratory studies many aspects of DNA damage responsive and DNA repair pathways, which include Radiation-induced DNA damage response (DDR), BRCA1/2 and homologous recombination repair, Replication stress pathway and lesion bypass, Fanconi anemia pathway and interstrand crosslink repair, Spartan/C1orf124/DVC1 and DNA-protein crosslink repair, and more recently the roles of DNA damage response in innate immunity. We also conduct mass spectrometry-based proteomics studies of various signaling pathways involved in tumorigenesis, recently focusing on Hippo/YAP and LBK1-AMPK pathways. In addition, we perform whole genome CRISPR/Cas9 screens to investigate gene-gene and drug-gene interactions involved in cancer development and cancer therapy.

Rotation students are welcome to participate in any of these studies.


MDACC Faculty

Junjie Chen Lab

Education & Training

PhD, University of Vermont, 1993

Research Info

DNA damage response and DNA repair; functional proteomics