The Cancer Biology Program at The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences (GSBS) in Houston is dedicated to providing students with the highest quality of training in diverse areas of cancer biology research.
Given the unique environment of the Texas Medical Center, the philosophy of the Cancer Biology Program is to supplement traditional graduate school training with both depth and breadth of knowledge in cancer biology.
Students will follow the standard format of choosing a single mentor who will guide an independent research project. However, our students frequently use the resources and expertise of several laboratories in different departments during the development of their cancer-related dissertation projects. This training provides a rich experience that increases the expertise and competitiveness of our graduates.
Currently, we have about 50 students and 120 faculty affiliated with the program. Our students have been among the most outstanding and productive of the GSBS. They also have been the recipients of many GSBS awards, as well as nationally competitive awards and fellowships. Like the faculty, the students bring wide-ranging perspectives and goals to their research. The program excels in accommodating these interests while fostering interactions among all of our students.
The program faculty are eager to train motivated students, and will gladly provide additional information with respect to their research programs and training opportunities in their laboratories.
This is an exciting new era in cancer research. A systematic training in cancer biology should allow our students to meet the challenge of Making Cancer History.
Award Winning Students
Mary Fuentes (mentor: Pawel Mazur, PhD) has been selected as one of the recipients of the 2018-2019 Sylvan Rodriguez Foundation Scholarship honoring George M. Stancel, Ph.D. which is awarded to GSBS pre-candidacy students who demonstrate the potential to be both outstanding cancer researchers and contributors to public awareness about cancer research.
Shelley Herbrich (mentor: Marina Konopleva, MD, PhD). (1) Recipient of the 2018-2019 Schissler Foundation Fellowship. (2) Selected by the Student Scholarship Committee and the GSBS Deans as the recipient of the 2018-2019 Cancer Answers/Sylvan Rodriguez Scholarship. This $5,000 Scholarship is awarded to a GSBS doctoral candidate who is doing promising cancer research and has also made significant contributions to community service and/or the promotion of science education.
Carolina Garcia-Garcia (mentor: Cullen Taniguchi, MD, PhD). (1) Recipient of 2017-2018 Sylvan Rodriguez Foundation Scholarship honoring George M. Stancel, Ph.D. (2) Selected by the GSBS Student Scholarship Committee and the GSBS Deans as the recipient of the 2018-2019 Ellen Taylor Goldin Legacy Scholarship. This $5,000 Scholarship is intended to recognize exceptional graduate students with interests related to radiation sciences.
Mei-Kuang Chen (mentor: Mien-Chie Hung, PhD). (1) Winner of the 2017-2018 Larry Deaven PhD Fellowship in Biomedical Sciences. (2) Selected by the GSBS Student Scholarship Committee and the GSBS Deans as the recipient of the 2018-2019 Jesse B. Heath, Jr. Family Legacy Award. This year, this $5,000 scholarship has been designated to recognize an exceptional GSBS student whose research project is in the areas of Cancer Signaling.
Dong Ho Shin (mentor: Juan Fueyo, MD). Selected by the GSBS Deans to receive a Terry and Janet Klebe Fellowship. This fellowship will cover the entire graduate research assistantship (GRA) including stipend, benefits and tuition/fees from October 1, 2018 – September 30, 2019. In addition to this GRA support, it will also provide an additional $4,000 scholarship.
Abdallah Mohamed (mentor: Clifton Fuller, MD, PhD). Selected by the Student Scholarship Committee and the GSBS Deans as one of the recipients of the 2018-2019 Andrew Sowell-Wade Huggins Scholarship in Cancer Research. These $5,000 Scholarships are awarded to GSBS doctoral candidates who are doing promising, high-impact cancer research.
Lisa Becker (mentor: Raghu Kalluri, MD, PhD). (1) Recipient of the 2017-2018 Andrew Sowell-Wade Huggins Scholarship in Cancer Research. (2) Recipient of the Rosalie B. Hite Fellowship for academic year 2018-2019.
Ryan Nini (mentor: Peter Friedl, MD, PhD). Recipient of the 2018-2019 Scholarship for Excellence in Biochemistry and Molecular Biology at MD Anderson Cancer Center.
Grant Fischer (mentor: Michael Davies, MD, PhD). Recipient of the 2018-2019 Schissler Foundation Fellowship.
Jena Leigh Tavormina (mentor: Raghu Kalluri, MD, PhD). (1) Winner of the 2017-2018 Deans Outreach Impact Awards. (2) Recipient of 2017-2018 Tzu Chi Foundation Scholarship Award for Excellence. (3) Recipient of the 2018 Linda M. Wells GSBS Outreach Award. (4) Selected by the GSBS Student Scholarship Committee and the GSBS Deans as one of the recipients of the 2018-2019 T.C. Hsu Memorial Scholarship.
Yifan Wang (mentor: Steven H. Lin, MD, PhD). (1) Recipient of the 2017-2018 T.C. Hsu Memorial Scholarship. (2) Winner of the 2017-2018 Scholarship for Excellence in Biochemistry and Molecular Biology at MD Anderson Cancer Center.
Marimar de la Cruz Bonilla (mentor: Helen Piwnica-Worms, PhD). (1) Winner of the 2017-2018 Cancer Answers/Sylvan Rodriguez Scholarship (2) Recipient of the Charlene Kopchick Fellowship and winner of the 2017-2018 Cancer Answers/Sylvan Rodriguez Scholarship.
Vincent Bernard (mentor: Anirban Maitra, MBBS). (1) Winner of the 2017-2018 American Legion Auxiliary Fellowship in Cancer Research. (2) Winner of the 2017 GSBS Presidents’ Research Scholarships.
Sarah Glazer (mentor: David Piwnica-Worms, MD, PhD). Recipient of 2017-2018 Sylvan Rodriguez Foundation Scholarship honoring George M. Stancel, Ph.D.
Suela Shin (mentor: Jian Hu, PhD). Recipient of the 2017-2018 Sam Taub and Beatrice Burton Endowed Fellowship in Vision Disease.
Estefania Labanca (mentor: Nora Navone, PhD). (1) Recipient of the 2017-2018 Floyd Haar, MD Endowed Memorial Scholarship in Memory of Freda Haar. (2) Selected by the GSBS Student Scholarship Committee and the GSBS Deans as one of the recipients of the 2018-2019 T.C. Hsu Memorial Scholarship.
Available Training Grants
High Impact Student Publications
Lin SH, Raju GS, Huff C, Ye Y, Gu J, Chen JS, Hildebrandt MAT, Liang H, Menter DG, Morris J, Hawk E, Stroehlein JR, Futreal A, Kopetz S, Mishra L, Wu X.
Gut. 2017 Jun 12. pii: gutjnl-2016-313573. doi: 10.1136/gutjnl-2016-313573. [Epub ahead of print]
Kurywchak P, Kalluri R.
Cell Res. 2017 Jun;27(6):722-723. doi: 10.1038/cr.2017.74. Epub 2017 May 19.
Wang Y, Liu H, Diao L, Potter A, Zhang J, Qiao Y, Wang J, Proia DA, Tailor R, Komaki R, Lin SH.
Clin Cancer Res. 2016 Dec 1;22(23):5876-5886. Epub 2016 Jun 28.
Lee SH, Chen TY, Dhar SS, Gu B, Chen K, Kim YZ, Li W, Lee MG.
Nucleic Acids Res. 2016 Dec 15;44(22):10603-10618. Epub 2016 Sep 12.
Doostan I, Karakas C, Kohansal M, Low KH, Ellis MJ, Olson JA Jr, Suman VJ, Hunt KK, Moulder SL, Keyomarsi K.
Clin Cancer Res. 2017 Dec 1;23(23):7288-7300. doi: 10.1158/1078-0432.CCR-17-1544. Epub 2017 Sep 25.
Cyclin E Associates with the Lipogenic Enzyme ATP-Citrate Lyase to Enable Malignant Growth of Breast Cancer Cells.
Lucenay KS, Doostan I, Karakas C, Bui T, Ding Z, Mills GB, Hunt KK, Keyomarsi K.
Cancer Res. 2016 Apr 15;76(8):2406-18. doi: 10.1158/0008-5472.CAN-15-1646. Epub 2016 Feb 29.
Pan R, Hogdal LJ, Benito JM, Bucci D, Han L, Borthakur G, Cortes J, DeAngelo DJ, Debose L, Mu H, Döhner H, Gaidzik VI, Galinsky I, Golfman LS, Haferlach T, Harutyunyan KG, Hu J, Leverson JD, Marcucci G, Müschen M, Newman R, Park E, Ruvolo PP, Ruvolo V, Ryan J, Schindela S, Zweidler-McKay P, Stone RM, Kantarjian H, Andreeff M, Konopleva M, Letai AG.
Cancer Discov. 2014 Mar;4(3):362-75. doi: 10.1158/2159-8290.CD-13-0609. Epub 2013 Dec 17.
Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy.
Pan R, Ruvolo V, Mu H, Leverson JD, Nichols G, Reed JC, Konopleva M, Andreeff M.
Cancer Cell. 2017 Dec 11;32(6):748-760.e6. doi: 10.1016/j.ccell.2017.11.003.
Peng DH, Ungewiss C, Tong P, Byers LA, Wang J, Canales JR, Villalobos PA, Uraoka N, Mino B, Behrens C, Wistuba II, Han RI, Wanna CA, Fahrenholtz M, Grande-Allen KJ, Creighton CJ, Gibbons DL.
Oncogene. 2017 Apr 6;36(14):1925-1938. doi: 10.1038/onc.2016.358. Epub 2016 Oct 3.
Roh W, Chen PL, Reuben A, Spencer CN, Prieto PA, Miller JP, Gopalakrishnan V, Wang F, Cooper ZA, Reddy SM, Gumbs C, Little L, Chang Q, Chen WS, Wani K, De Macedo MP, Chen E, Austin-Breneman JL, Jiang H, Roszik J, Tetzlaff MT, Davies MA, Gershenwald JE, Tawbi H, Lazar AJ, Hwu P, Hwu WJ, Diab A, Glitza IC, Patel SP, Woodman SE, Amaria RN, Prieto VG, Hu J, Sharma P, Allison JP, Chin L, Zhang J, Wargo JA, Futreal PA.
Sci Transl Med. 2017 Mar 1;9(379). pii: eaah3560. doi: 10.1126/scitranslmed.aah3560. Erratum in: Sci Transl Med. 2017 Apr 12;9(385):.
Chen PL, Roh W, Reuben A, Cooper ZA, Spencer CN, Prieto PA, Miller JP, Bassett RL, Gopalakrishnan V, Wani K, De Macedo MP, Austin-Breneman JL, Jiang H, Chang Q, Reddy SM, Chen WS, Tetzlaff MT, Broaddus RJ, Davies MA, Gershenwald JE, Haydu L, Lazar AJ, Patel SP, Hwu P, Hwu WJ, Diab A, Glitza IC, Woodman SE, Vence LM, Wistuba II, Amaria RN, Kwong LN, Prieto V, Davis RE, Ma W, Overwijk WW, Sharpe AH, Hu J, Futreal PA, Blando J, Sharma P, Allison JP, Chin L, Wargo JA.
Cancer Discov. 2016 Aug;6(8):827-37. doi: 10.1158/2159-8290.CD-15-1545. Epub 2016 Jun 14.
SnapShot: Stress and Disease.
Nagaraja AS, Sadaoui NC, Dorniak PL, Lutgendorf SK, Sood AK.
Cell Metab. 2016 Feb 9;23(2):388-388.e1. doi: 10.1016/j.cmet.2016.01.015.
Kang Y, Nagaraja AS, Armaiz-Pena GN, Dorniak PL, Hu W, Rupaimoole R, Liu T, Gharpure KM, Previs RA, Hansen JM, Rodriguez-Aguayo C, Ivan C, Ram P, Sehgal V, Lopez-Berestein G, Lutgendorf SK, Cole SW, Sood AK.
Clin Cancer Res. 2016 Apr 1;22(7):1713-24. doi: 10.1158/1078-0432.CCR-15-1275. Epub 2015 Nov 18.
Sympathetic nervous system regulation of the tumour microenvironment.
Cole SW, Nagaraja AS, Lutgendorf SK, Green PA, Sood AK.
Nat Rev Cancer. 2015 Sep;15(9):563-72. doi: 10.1038/nrc3978. Review.
Sustained adrenergic signaling leads to increased metastasis in ovarian cancer via increased PGE2 synthesis.
Nagaraja AS, Dorniak PL, Sadaoui NC, Kang Y, Lin T, Armaiz-Pena G, Wu SY, Rupaimoole R, Allen JK, Gharpure KM, Pradeep S, Zand B, Previs RA, Hansen JM, Ivan C, Rodriguez-Aguayo C, Yang P, Lopez-Berestein G, Lutgendorf SK, Cole SW, Sood AK.
Oncogene. 2016 May 5;35(18):2390-7. doi: 10.1038/onc.2015.302. Epub 2015 Aug 10.
Why stress is BAD for cancer patients.
Nagaraja AS, Armaiz-Pena GN, Lutgendorf SK, Sood AK.
J Clin Invest. 2013 Feb;123(2):558-60. doi: 10.1172/JCI67887. Epub 2013 Jan 25.
te Boekhorst, Veronika
Lehmann S, Te Boekhorst V, Odenthal J, Bianchi R, van Helvert S, Ikenberg K, Ilina O, Stoma S, Xandry J, Jiang L, Grenman R, Rudin M, Friedl P.
Curr Biol. 2017 Feb 6;27(3):392-400. doi: 10.1016/j.cub.2016.11.057. Epub 2017 Jan 12.
Plasticity of Cancer Cell Invasion-Mechanisms and Implications for Therapy.
Te Boekhorst V, Friedl P.
Adv Cancer Res. 2016;132:209-64. doi: 10.1016/bs.acr.2016.07.005. Epub 2016 Aug 17. Review.
Plasticity of Cell Migration In Vivo and In Silico.
Te Boekhorst V, Preziosi L, Friedl P.
Annu Rev Cell Dev Biol. 2016 Oct 6;32:491-526. Epub 2016 Aug 26. Review.
Histone Deacetylase Inhibitor Enhances the Efficacy of MEK Inhibitor through NOXA-Mediated MCL1 Degradation in Triple-Negative and Inflammatory Breast Cancer.
Torres-Adorno AM, Lee J, Kogawa T, Ordentlich P, Tripathy D, Lim B, Ueno NT.
Clin Cancer Res. 2017 Aug 15;23(16):4780-4792. doi: 10.1158/1078-0432.CCR-16-2622. Epub 2017 May 2.
CDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers.
Vijayaraghavan S, Karakas C, Doostan I, Chen X, Bui T, Yi M, Raghavendra AS, Zhao Y, Bashour SI, Ibrahim NK, Karuturi M, Wang J, Winkler JD, Amaravadi RK, Hunt KK, Tripathy D, Keyomarsi K.
Nat Commun. 2017 Jun 27;8:15916. doi: 10.1038/ncomms15916.
Wei D, Wang L, Yan Y, Jia Z, Gagea M, Li Z, Zuo X, Kong X, Huang S, Xie K.
Cancer Cell. 2016 Mar 14;29(3):324-38. doi: 10.1016/j.ccell.2016.02.005.