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Jae-il Park

Jae-il Park

Regular Member


MDA Z6.3034 (Unit 0066)

The University of Texas MD Anderson Cancer Center
Department of Experimental Radiation Oncology

We are studying stem cells and cancer using genetically engineered mouse models and organoids with a specific interest in Wnt signaling

Wnt signaling plays key roles in governing various cellular processes during embryogenesis, organogenesis, and tissue homeostasis. We are exploring how Wnt signaling controls tissue stem and progenitor cells and orchestrates tissue regeneration.

Aberrant activation of Wnt signaling contributes to cancer. Given the crucial roles of Wnt signaling in tissue homeostasis and regeneration, direct targeting of Wnt signaling as a cancer treatment is challenging. To overcome this, we are in the study of new molecules, cancer-specific regulators of Wnt signaling, in a pre-clinical setting.


MDACC Faculty

Park Lab

Education & Training

Ph.D. - MD Anderson UTHealth Graduate School - 2006

Research Info

tissue stem cells in regeneration and development; cell plasticity in tissue homeostasis and cancer; Wnt signaling in cancer