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Jan Parker-Thornburg

Jan Parker-Thornburg

Associate Member

Professor

713.745.2654713.745.2654
jpthorn@mdanderson.org
MDA SB.8052 (Unit 110)

The University of Texas MD Anderson Cancer Center
Department of Genetics

Dr. Parker-Thornburg co-directs the GEMF at M.D. Anderson Cancer Center.  In that capacity, she performs collaborative science that enables Center investigators to obtain critical animal models for their research.  The animal models produced in the GEMF have contributed to many high-impact publications from Cancer Center faculty.  In addition to collaborative projects, Dr. Parker-Thornburg performs research to both extend and refine the technology involved in the generation and archiving of genetically modified mice.  A recent focus has been the use of CRISPR/Cas9 technology for animal model production. In collaboration with Dr. Richard Behringer to produce CRISPR/Cas9 mice, it was shown that significant mosaicism can be expected in the founder generation after CRISPR/Cas9 pronuclear injection. Dr. Parker-Thornburg also participated in the analysis of a new inbred mouse strain—SKHIN/Sprd—by demonstrating that this hairless strain could be used for pronuclear injection to create transgenic mice in a hairless background.  Further technology refinements have included analyses of anesthesia modalities and their effects upon birth rate after implantation surgery, superovulation in six common mouse strains and how cryopreserved embryos can be used for blastocyst injection.  The lab is now involved in investigating new methods of producing conditional mouse models and enhancing homology-driven repair in CRISPR models.

Research Interests

  • Genetic Engineering of animals
  • CRISPR/Cas9 technology
  • Assisted Reproductive technologies
  • Mouse modeling

PubMed

MDACC Faculty

MD Anderson Genetically Engineered Mouse Facility 

Education & Training

Ph.D. - Indiana University - 1990