The University of Texas Health Science Center at Houston
McGovern Medical School
Department of Neurosurgery

Research in the McBride Cerebrovascular Laboratory is focused on understanding the mechanisms causing delayed neurological deficits after subarachnoid hemorrhage (SAH) and identifying novel therapeutic targets. Our current work revolves around brain blood vessel constriction and microthrombosis which are thought to be major contributors to delayed neurological deficits after SAH. We are using animal models of SAH, as well as cell culture, to elucidate the pathophysiological mechanisms of delayed deficits and determine potential therapeutic targets to prevent such functional injury. We are also collaborating with Spiros Blackburn to identify the changes in coagulation and platelet function after SAH as potential biomarkers for delayed neurological deficits and poor outcome in patients.

CURRENT PROJECTS

Investigate the role of platelets in microthrombi formation after SAH

Determine the therapeutic potential of galantamine for preventing inflammation after SAH

Evaluate the haptoglobin-CD163 axis for hemoglobin clearance after SAH

PubMed

McGovern Medical School Faculty

Education & Training

Ph.D., University of California Riverside, 2013