The University of Texas MD Anderson Cancer Center
Department of Translational Molecular Pathology
Little is known about the genetic pathways that discriminate breast cancer in young women from those that occur more commonly in the general population with later age of onset. Our laboratory has identified a novel tumor suppressor gene DEAR1 which we have evidence of its role in the evolution of breast cancer and for its potential as a prognostic marker in early onset breast cancer. Functional characterization studies indicate that DEAR1 regulates polarity and acinar morphogenesis in 3D culture. A major project in the laboratory involves the characterization of DEAR1 function to elucidate its role in development and cancer.
Our laboratory is also a biomarker discovery laboratory funded by the Early Detection Research Network at the National Cancer Institute. Goals in this regard are focused on the use of functional genomic strategies to identify pathways aberrant in pancreatic cancer from which novel biomarkers for the early detection of pancreatic cancer can be identified.
Education & Training
Ph.D. - MD Anderson UTHealth Graduate School - 1981