The University of Texas MD Anderson Cancer Center
Departments of Experimental Therapeutics and Translational Molecular Pathology

My long term scientific career goal is to establish the roles of non-coding RNAs in human diseases. In order to accomplish this, I plan to continue and expand in the next few years my previous work in the following way:

1. Identification of the Roles of microRNAs and Other Non-Coding RNAs in Cancer Predisposition
2. Identification of Non-Coding RNAs Involved in Metastasis
3. Identification of microRNAs and Other Non-Coding RNAs as Diagnostic and Prognostic Markers in Human Cancers microRNAs as the Oldest Hormones
4. Development of New Therapeutic Strategies Involving microRNAs and Other Non-Coding RNAs

Students rotating in the Calin laboratory would learn:

• Genomics techniques related to non-codingRNAs (such as cloning, identification of genomics alterations or sequence variations)
• Expression studies (by Northern blottings, quantitative PCr or microarray technology)
• Identification of clinical and prognostic correlations between the different molecular signatures that we will identify and the clinical parameters
• Achieve skills in the standard techniques used for construction of viral vectors important for the initial studies of gene therapy with microRNAs

PubMed

MDACC Faculty

Calin Lab

Education & Training

MD, Carol Davila University of Medicine and Pharmacy, 1992
PhD, Carol Davila University of Medicine and Pharmacy, 2000

Programs

• Cancer Biology
• Therapeutics and Pharmacology

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Faculty Development

• Mentoring Works

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