Kai Xu
Associate Professor
The University of Texas Health Science Center at Houston
McGovern Medical School
Department of Immunology - Texas Therapeutic Institute
Viruses pose significant threats to human health, from mild ailments like the common cold to severe conditions such as AIDS. Understanding viral infection and the immune response is crucial in biomedical research and public health. Our research aims to uncover the intricate interactions between viruses and host cells, shedding light on how viruses are captured by or evade immune detection. This understanding is critical for developing effective antiviral therapies and informing vaccine design strategies. We integrate immunology, structural biology, virology, biochemistry, and bioinformatics to understand and combat viral diseases. Our work spans viral pathogens, including HIV, SARS-CoV-2, influenza, and emerging zoonotic viruses.
Prospective trainees will engage in diverse projects to elucidate the structural and functional basis of viral infection and immune recognition. They will practice basic lab experiments like molecular cloning, cell culture, protein purification, and protein binding analysis. Moreover, they will explore advanced techniques, including Electron Microscopy single-particle analysis, X-ray crystallography, mouse immunization studies, immunological assessments, antibody isolation through phage-display library screening, and viral neutralization assays. Furthermore, trainees will be introduced to cutting-edge methodologies such as structure-based drug design and AI-based protein engineering and gain insight into the forefront of biomedical research.
Through hands-on experience, trainees will acquire proficiency in fundamental laboratory skills and select advanced techniques, nurturing their critical thinking capabilities, which equip them to analyze experimental data objectively, identify research challenges, and devise innovative solutions. By collaborating with multidisciplinary teams, trainees will play a crucial role in advancing our comprehension of viral diseases and ultimately enhancing global health outcomes.
Education & Training
PhD, Cornell Medical College, 2009