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Long-Jun Wu

Long-Jun Wu

Regular Member


The University of Texas Health Science Center at Houston
McGovern Medical School

Center for Neuroimmunology and Glial Biology

Dr. Long-Jun Wu is C. Harold and Lorine G. Wallace Distinguished University Chair, Professor and Founding Director of Center for Neuroimmunology and Glial Biology, Institute of Molecular Medicine, UTHealth Houston McGovern Medical School. Dr. Wu received his PhD in Neurobiology and Biophysics from University of Science and Technology of China in 2004. He obtained his postdoctoral trainings at University of Toronto and Harvard Medical School. He was Professor of Neurology and Neuroscience at Mayo Clinic prior to joining UTHealth Houston.

Dr. Wu’ research mainly focuses on neuroimmune interaction in health and disease. Particularly, he is interested in studying the role of microglia, the highly dynamic immune cells in the central nervous system, in clinically relevant pathologies such as epilepsy, neuropathic pain, neurodegeneration, and autoimmune neurology. Dr. Wu and his team use advanced genetic tools along with a combination of two-photon imaging, electrophysiology, electroencephalography, molecular biology techniques and awake-behavioral studies in rodent models. His group recently uncovered the molecular mechanism underlying microglial sensing and regulation of neuronal activities in normal and diseased brain (Liu et al. Nat Neurosci, 2019; Xie et al., Nat Neurosci, 2022; Haruwaka et al., Nat Neurosci, 2024; Umpierre et al., Neuron, in press). The current research in Dr Wu’s laboratory include: (1) Microglia-synapse interaction; (2) Microglial TREM2 function; (3) Microglial calcium signaling; (4) Microglia-T cells interaction; (5) Monocytes infiltration and function. By understanding the cross talk between nervous system and immune system, the long-term vision of Dr. Wu’s research is to identify neuroimmune mechanisms and microglia-specific targets to treat neurological disorders and neurodegeneration.


Wu Lab

Education & Training

PhD, University of Science and Technology of China, 2004