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Sangeeta Goswami

Sangeeta Goswami

Regular Member

Assistant Professor

[email protected]
Duncan Building - CPB7.3512

The University of Texas MD Anderson Cancer Center
Department of Genitourinary Medical Oncology & Immunology

The research in my laboratory focuses on identifying pathways of response and resistance to
immune-based therapies including immune checkpoint therapy. The tumor immune
microenvironment is extremely dynamic. Tumor and immune cell subsets demonstrate
significant plasticity and evolve into different functional states based on the cues received from
the microenvironment. One of the critical pathways that regulate the functional phenotype of
tumor and immune cell subsets is epigenetic regulation. Based on the basic mechanistic
understanding of these processes, we aim to develop strategies to target specific pathways to
overcome primary and adaptive resistance to immune-based therapies. We have identified
critical epigenetic pathways that regulate functional phenotypes of T cells and myeloid cells
which are currently being tested in the clinic.

MDACC Faculty

Education & Training

MD - Gauhati Medical College - 2001
PhD - Baylor College of Medicine - 2009