The University of Texas MD Anderson Cancer Center
Department of Pediatrics Research
In the Schadler lab, we have two broad categories of interest: tumor vascular biology and the utilization of moderate aerobic exercise as a therapeutic adjuvant during cancer treatment or stem cell transplant. We use mouse models of pediatric bone sarcomas and melanoma to a) determine the molecular pathways in tumor endothelium that regulate the vascular response to exercise; b) determine how the anti-tumor immune response is changed by exercise; c) determine whether exercise and diet modifications can be used to protect against chemotherapy-induced cardiac toxicity; d) identify potential therapeutic targets in tumor endothelium to induce tumor vessel normalization; e) determine how aerobic exercise affects tumor metastasis. Additionally, we use mouse models of veno-occlusive disease (VOD), which is frequently fatal for stem cell transplant patients, to delineate the role of endothelium in VOD. We are a largely translational lab, and collaborate closely with clinicians in order to perform clinical trials in which cancer patients participate in exercise studies. Rotation projects in this lab will likely include a combination of mouse work, immunohistochemical evaluation, and other molecular biology techniques.
Education & Training
PhD, MD Anderson UTHealth Graduate School, 2010