Aloke Sarkar
Associate Member
Assistant Professor
The University of Texas MD Anderson Cancer Center at Houston
Department of Experimental Therapeutics
Mitochondrial damage has been associated with several diseases, including cancer. Dysfunctional mitochondria (DyM) are eliminated via a unique process called mitochondrial autophagy (mitophagy). Understanding mechanisms of exclusion of damaged mitochondria is therefore key for discerning therapeutic susceptibilities in cancer cells. Recently, we and others identified a novel non-nuclear role of the master DNA damage sensor protein Ataxia telangiectasia mutated (ATM) in regulating mitophagy in multiple cancer cell lines.
Education & Training
PhD - Jadavpur University - 1996