The University of Texas Health Science Center at Houston
McGovern Medical School
Institute of Molecular Medicine
Center for Metabolic and Degenerative Diseases
The Kolonin Laboratory is investigating the mechanisms linking aging, metabolic diseases such as type-2 diabetes, and cancer. Specifically, we have focused on the role of white and brown fat tissue dysfunction in obesity. In clinical studies and in animal models, we have shown that mesenchymal stromal cells from adipose tissue are mobilized to promote fibrosis and cancer progression. Studies elucidating the molecular mechanisms of intercellular interactions between adipose and other tissues are underway. Our group has also taken the lead in developing approaches to intervene the pathogenic functions of adipose cells. Based on the expertise in cell population separation and high throughput combinatorial peptide library screening methods, we have identified tissue-specific cell surface receptors and peptide probes. Using peptide-derived experimental drugs, we have developing a strategy to target specific cell populations in order to suppress the progression various diseases.
Students rotating in the laboratory would have an opportunity to learn:
- Methods to analyze functional interactions between various cell types.
- Technology of combinatorial peptide library screening based on phage display.
- Methods to study metabolism and cancer in mouse models and clinical samples
- Mesenchymal stem cells and fibrosis
- Adipose stroma trafficking and signaling
- Cell metabolism in obesity and cancer
- Clinical sample analysis, mouse models
- Combinatorial library screening
- Experimental targeted therapeutics
Education & Training
Ph.D. - Wayne State University - 2000